DagsHub-Datasets
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dandiarchive-dataset


  
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            {"id":"DANDI:001047/draft","url":"https://dandiarchive.org/dandiset/001047/draft","name":"Optimizing NG-CanCan Protocol Delivery with MHz Compression to Minimize Near-Electrode Ablation","about":[],"access":[{"status":"dandi:OpenAccess","schemaKey":"AccessRequirements"}],"license":["spdx:CC-BY-4.0"],"version":"draft","@context":"https://raw.githubusercontent.com/dandi/schema/master/releases/0.6.7/context.json","citation":"Silkuniene, Giedre; Silkunas, Mantas; Pakhomov, Andrei (2025) Optimizing NG-CanCan Protocol Delivery with MHz Compression to Minimize Near-Electrode Ablation (Version draft) [Data set]. DANDI Archive. https://dandiarchive.org/dandiset/001047/draft","schemaKey":"Dandiset","identifier":"DANDI:001047","repository":"https://dandiarchive.org","contributor":[{"name":"Silkuniene, Giedre","email":"giedre.silkuniene@gmail.com","roleName":["dcite:ContactPerson"],"schemaKey":"Person","identifier":"0000-0001-8436-9718","affiliation":[],"includeInCitation":true},{"name":"Silkunas, Mantas","schemaKey":"Person","identifier":"0000-0002-4568-9265","includeInCitation":true},{"name":"Pakhomov, Andrei","roleName":["dcite:ProjectLeader"],"schemaKey":"Person","identifier":"0000-0003-3816-3860","includeInCitation":true},{"name":"National Institutes of Health","roleName":["dcite:Funder"],"schemaKey":"Organization","awardNumber":"1R21EY034258","includeInCitation":false},{"name":"Semenov, Iurii","schemaKey":"Person","identifier":"0000-0002-0302-1355"},{"name":"Pakhomova, Olga","schemaKey":"Person","identifier":"0000-0003-4950-4130"}],"dateCreated":"2024-06-04T17:21:04.141576+00:00","description":"This study advanced the Next Generation (NG) CanCan protocols by implementing MHz compression for electric pulse packet delivery. Packets were delivered at 0.2 MHz, and the compression significantly reduced near-electrode cell ablation compared to delivery at 1 Hz, while preserving effects at the center. The experiments used a four-electrode array, with YoPro-1 to evaluate cell permeabilization and Propidium Iodide to assess cell death two hours post-delivery. This work was supported by NIH grant 1R21EY034258.","assetsSummary":{"schemaKey":"AssetsSummary","numberOfBytes":0,"numberOfFiles":0},"schemaVersion":"0.6.7","ethicsApproval":[],"wasGeneratedBy":[{"name":"Targeted Neuromodulation by Nanosecond Pulsed Electric Fields","schemaKey":"Project","identifier":"NIH 1R21EY034258"}],"relatedResource":[{"url":"https://doi.org/10.1016/j.bioelechem.2025.109016","name":"MHz compression of pulse packets facilitates remote focusing of electroporation","relation":"dcite:IsPublishedIn","schemaKey":"Resource","identifier":"doi.org/10.1016/j.bioelechem.2025.109016","resourceType":"dcite:JournalArticle"}],"manifestLocation":["https://api.dandiarchive.org/api/dandisets/001047/versions/draft/assets/"]}