dandiarchive-dataset/s3://dandiarchive/dandisets/001038/draft/dandiset.yaml

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about:
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  name: substantia nigra pars compacta
  schemaKey: Anatomy
- identifier: http://purl.obolibrary.org/obo/UBERON_0035999
  name: dopaminergic cell groups
  schemaKey: Anatomy
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  status: dandi:OpenAccess
assetsSummary:
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  dataStandard:
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    name: Neurodata Without Borders (NWB)
    schemaKey: StandardsType
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  numberOfSubjects: 105
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  species:
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    name: Mus musculus - House mouse
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citation: Azcorra, Maite; Gaertner, Zachary; Davidson, Connor; He, Qianzi; Kim, Hailey;
  Nagappan, Shivathmihai; Hayes, Cooper K.; Ramakrishnan, Charu; Fenno, Lief; Kim,
  Yoon Seok; Deisseroth, Karl; Longnecker, Richard; Awatramani, Rajeshwar; Dombeck,
  Daniel A. (2024) Unique functional responses differentially map onto genetic subtypes
  of dopamine neurons (Version draft) [Data set]. DANDI archive. https://dandiarchive.org/dandiset/001038/draft
contributor:
- affiliation: []
  identifier: 0000-0002-2919-3825
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  name: Azcorra, Maite
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  identifier: 0000-0002-1760-6549
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  name: Gaertner, Zachary
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  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Davidson, Connor
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  - dcite:Author
  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: He, Qianzi
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  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Kim, Hailey
  roleName:
  - dcite:Author
  schemaKey: Person
- affiliation: []
  includeInCitation: true
  name: Nagappan, Shivathmihai
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  schemaKey: Person
- affiliation: []
  identifier: 0000-0003-2419-0286
  includeInCitation: true
  name: Hayes, Cooper K.
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  identifier: 0000-0002-3474-6332
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  name: Ramakrishnan, Charu
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  identifier: 0000-0002-5237-6179
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  name: Fenno, Lief
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- affiliation: []
  includeInCitation: true
  name: Kim, Yoon Seok
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- affiliation: []
  identifier: 0000-0001-9440-3967
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  name: Deisseroth, Karl
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  name: Longnecker, Richard
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  identifier: 0000-0002-0713-2140
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  name: Awatramani, Rajeshwar
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  email: d-dombeck@northwestern.edu
  identifier: 0000-0003-2576-5918
  includeInCitation: true
  name: Dombeck, Daniel A.
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- awardNumber: ASAP-020600
  identifier: https://ror.org/03arq3225
  includeInCitation: false
  name: Michael J. Fox Foundation
  roleName:
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  schemaKey: Organization
- awardNumber: R01MH110556
  identifier: https://ror.org/01cwqze88
  includeInCitation: false
  name: National Institutes of Health
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  schemaKey: Organization
- awardNumber: ' 1R01NS119690-01'
  identifier: https://ror.org/01s5ya894
  includeInCitation: false
  name: National Institute of Neurological Disorders and Stroke
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  name: National Institute on Drug Abuse
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  identifier: https://ror.org/04q48ey07
  includeInCitation: false
  name: National Institute of General Medical Sciences
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  name: National Cancer Institute
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dateCreated: '2024-05-24T13:54:10.941834+00:00'
description: Dopamine neurons are characterized by their response to unexpected rewards,
  but they also fire during movement and aversive stimuli. Dopamine neuron diversity
  has been observed based on molecular expression profiles; however, whether different
  functions map onto such genetic subtypes remains unclear. In this study, we established
  that three genetic dopamine neuron subtypes within the substantia nigra pars compacta,
  characterized by the expression of Slc17a6 (Vglut2), Calb1 and Anxa1, each have
  a unique set of responses to rewards, aversive stimuli and accelerations and decelerations,
  and these signaling patterns are highly correlated between somas and axons within
  subtypes. Remarkably, reward responses were almost entirely absent in the Anxa1+
  subtype, which instead displayed acceleration-correlated signaling. Our findings
  establish a connection between functional and genetic dopamine neuron subtypes and
  demonstrate that molecular expression patterns can serve as a common framework to
  dissect dopaminergic functions.
ethicsApproval: []
id: DANDI:001038/draft
identifier: DANDI:001038
keywords:
- Fiber photometry
- GCaMP6f
- Dopamine
- 'substantia nigra pars compacta '
- striatum
license:
- spdx:CC-BY-4.0
manifestLocation:
- https://api.dandiarchive.org/api/dandisets/001038/versions/draft/assets/
name: Unique functional responses differentially map onto genetic subtypes of dopamine
  neurons
protocol:
- https://www.protocols.io/view/acute-striatal-or-midbrain-fiber-photometry-in-hea-4r3l27yj4g1y/v1
- https://www.protocols.io/view/midbrain-viral-injections-for-striatal-fiber-photo-5qpvor8zxv4o/v1
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  url: https://doi.org/https://doi.org/10.1038/s41593-023-01401-9
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  repository: GitHub
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  url: https://github.com/DombeckLab/Azcorra2023/
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  name: Azcorra2023 - Raw fiber photometry recordings
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  name: Azcorra2023 - Fiber photometry recordings (pre-processed to get DF/F)
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  repository: GitHub
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  schemaKey: Resource
  url: https://github.com/catalystneuro/dombeck-lab-to-nwb
repository: https://dandiarchive.org
schemaKey: Dandiset
schemaVersion: 0.6.7
studyTarget: []
url: https://dandiarchive.org/dandiset/001038/draft
version: draft
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