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            {"id":"DANDI:001038/draft","url":"https://dandiarchive.org/dandiset/001038/draft","name":"Unique functional responses differentially map onto genetic subtypes of dopamine neurons","about":[{"name":"substantia nigra pars compacta","schemaKey":"Anatomy","identifier":"http://purl.obolibrary.org/obo/UBERON_0001965"},{"name":"dopaminergic cell groups","schemaKey":"Anatomy","identifier":"http://purl.obolibrary.org/obo/UBERON_0035999"}],"access":[{"status":"dandi:OpenAccess","schemaKey":"AccessRequirements"}],"license":["spdx:CC-BY-4.0"],"version":"draft","@context":"https://raw.githubusercontent.com/dandi/schema/master/releases/0.6.7/context.json","citation":"Azcorra, Maite; Gaertner, Zachary; Davidson, Connor; He, Qianzi; Kim, Hailey; Nagappan, Shivathmihai; Hayes, Cooper K.; Ramakrishnan, Charu; Fenno, Lief; Kim, Yoon Seok; Deisseroth, Karl; Longnecker, Richard; Awatramani, Rajeshwar; Dombeck, Daniel A. (2024) Unique functional responses differentially map onto genetic subtypes of dopamine neurons (Version draft) [Data set]. DANDI archive. https://dandiarchive.org/dandiset/001038/draft","keywords":["Fiber photometry","GCaMP6f","Dopamine","substantia nigra pars compacta ","striatum"],"protocol":["https://www.protocols.io/view/acute-striatal-or-midbrain-fiber-photometry-in-hea-4r3l27yj4g1y/v1","https://www.protocols.io/view/midbrain-viral-injections-for-striatal-fiber-photo-5qpvor8zxv4o/v1"],"schemaKey":"Dandiset","identifier":"DANDI:001038","repository":"https://dandiarchive.org","contributor":[{"name":"Azcorra, Maite","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-2919-3825","affiliation":[],"includeInCitation":true},{"name":"Gaertner, Zachary","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-1760-6549","affiliation":[],"includeInCitation":true},{"name":"Davidson, Connor","roleName":["dcite:Author"],"schemaKey":"Person","affiliation":[],"includeInCitation":true},{"name":"He, Qianzi","roleName":["dcite:Author"],"schemaKey":"Person","affiliation":[],"includeInCitation":true},{"name":"Kim, Hailey","roleName":["dcite:Author"],"schemaKey":"Person","affiliation":[],"includeInCitation":true},{"name":"Nagappan, Shivathmihai","roleName":["dcite:Author"],"schemaKey":"Person","affiliation":[],"includeInCitation":true},{"name":"Hayes, Cooper K.","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0003-2419-0286","affiliation":[],"includeInCitation":true},{"name":"Ramakrishnan, Charu","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-3474-6332","affiliation":[],"includeInCitation":true},{"name":"Fenno, Lief","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-5237-6179","affiliation":[],"includeInCitation":true},{"name":"Kim, Yoon Seok","roleName":["dcite:Author"],"schemaKey":"Person","affiliation":[],"includeInCitation":true},{"name":"Deisseroth, Karl","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0001-9440-3967","affiliation":[],"includeInCitation":true},{"name":"Longnecker, Richard","roleName":["dcite:Author"],"schemaKey":"Person","affiliation":[],"includeInCitation":true},{"name":"Awatramani, Rajeshwar","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-0713-2140","affiliation":[],"includeInCitation":true},{"name":"Dombeck, Daniel A.","email":"d-dombeck@northwestern.edu","roleName":["dcite:Author","dcite:ContactPerson"],"schemaKey":"Person","identifier":"0000-0003-2576-5918","affiliation":[],"includeInCitation":true},{"name":"Michael J. Fox Foundation","roleName":["dcite:Funder"],"schemaKey":"Organization","identifier":"https://ror.org/03arq3225","awardNumber":"ASAP-020600","includeInCitation":false},{"name":"National Institutes of Health","roleName":["dcite:Funder"],"schemaKey":"Organization","identifier":"https://ror.org/01cwqze88","awardNumber":"R01MH110556","includeInCitation":false},{"name":"National Institute of Neurological Disorders and Stroke","roleName":["dcite:Funder"],"schemaKey":"Organization","identifier":"https://ror.org/01s5ya894","awardNumber":" 1R01NS119690-01","includeInCitation":false},{"name":"National Institute on Drug Abuse","roleName":["dcite:Funder"],"schemaKey":"Organization","awardNumber":"P50 DA044121-01A1","includeInCitation":false},{"name":"National Institute of General Medical Sciences","roleName":["dcite:Funder"],"schemaKey":"Organization","identifier":"https://ror.org/04q48ey07","awardNumber":"5T32GM008152-34","includeInCitation":false},{"name":"National Cancer Institute","roleName":["dcite:Funder"],"schemaKey":"Organization","identifier":"https://ror.org/040gcmg81","awardNumber":"CA060553","includeInCitation":false}],"dateCreated":"2024-05-24T13:54:10.941834+00:00","description":"Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. Dopamine neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three genetic dopamine neuron subtypes within the substantia nigra pars compacta, characterized by the expression of Slc17a6 (Vglut2), Calb1 and Anxa1, each have a unique set of responses to rewards, aversive stimuli and accelerations and decelerations, and these signaling patterns are highly correlated between somas and axons within subtypes. Remarkably, reward responses were almost entirely absent in the Anxa1+ subtype, which instead displayed acceleration-correlated signaling. Our findings establish a connection between functional and genetic dopamine neuron subtypes and demonstrate that molecular expression patterns can serve as a common framework to dissect dopaminergic functions.","studyTarget":[],"assetsSummary":{"species":[{"name":"Mus musculus - House mouse","schemaKey":"SpeciesType","identifier":"http://purl.obolibrary.org/obo/NCBITaxon_10090"}],"approach":[],"schemaKey":"AssetsSummary","dataStandard":[{"name":"Neurodata Without Borders (NWB)","schemaKey":"StandardsType","identifier":"RRID:SCR_015242"}],"numberOfBytes":22630124235,"numberOfFiles":1232,"numberOfSubjects":105,"variableMeasured":["ProcessingModule"],"measurementTechnique":[{"name":"analytical technique","schemaKey":"MeasurementTechniqueType"}]},"schemaVersion":"0.6.7","ethicsApproval":[],"wasGeneratedBy":[],"relatedResource":[{"url":"https://doi.org/https://doi.org/10.1038/s41593-023-01401-9","name":"Unique functional responses differentially map onto genetic subtypes of dopamine neurons","relation":"dcite:IsDescribedBy","schemaKey":"Resource","identifier":"https://doi.org/10.1038/s41593-023-01401-9","repository":"Nature Neuroscience","resourceType":"dcite:JournalArticle"},{"url":"https://github.com/DombeckLab/Azcorra2023/","name":"Azcorra2023","relation":"dcite:IsSupplementedBy","schemaKey":"Resource","repository":"GitHub","resourceType":"dcite:Software"},{"url":"https://zenodo.org/records/7871634","name":"Azcorra2023 - Raw fiber photometry recordings","relation":"dcite:IsDerivedFrom","schemaKey":"Resource","identifier":"https://doi.org/10.5281/zenodo.7871634","repository":"Zenodo","resourceType":"dcite:Dataset"},{"url":"https://zenodo.org/records/7871982","name":"Azcorra2023 - Fiber photometry recordings (pre-processed to get DF/F)","relation":"dcite:IsDerivedFrom","schemaKey":"Resource","identifier":"https://doi.org/10.5281/zenodo.7871982","repository":"Zenodo","resourceType":"dcite:Dataset"},{"url":"https://github.com/catalystneuro/dombeck-lab-to-nwb","name":"dombeck-lab-to-nwb","relation":"dcite:IsCompiledBy","schemaKey":"Resource","repository":"GitHub","resourceType":"dcite:Software"}],"manifestLocation":["https://api.dandiarchive.org/api/dandisets/001038/versions/draft/assets/"]}