Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET)

Stream data with DDA:

from dagshub.streaming import DagsHubFilesystem

fs = DagsHubFilesystem(".", repo_url="https://dagshub.com/DagsHub-Datasets/targetepigenomics-dataset")

fs.listdir("s3://targetepigenomics")

Description:

The TaRGET (Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription) Program is a research consortium funded by the National Institute of Environmental Health Sciences (NIEHS). The goal of the collaboration is to address the role of environmental exposures in disease pathogenesis as a function of epigenome perturbation, including understanding the environmental control of epigenetic mechanisms and assessing the utility of surrogate tissue analysis in mouse models of disease-relevant environmental exposures.

Contact:

The TaRGET (Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription) Program is a research consortium funded by the National Institute of Environmental Health Sciences (NIEHS). The goal of the collaboration is to address the role of environmental exposures in disease pathogenesis as a function of epigenome perturbation, including understanding the environmental control of epigenetic mechanisms and assessing the utility of surrogate tissue analysis in mouse models of disease-relevant environmental exposures.

Update Frequency:

TaRGET-DCC offers monthly data releases, although this dataset may not be updated at every release.

Managed By:

TaRGET-DCC

Resources:

1. resource:
   • Description: Released and archived TaRGET II data
   • ARN: arn:aws:s3:::targetepigenomics
   • Region: us-west-2
   • Type: S3 Bucket

Tags:

biology, bioinformatics, genetic, genomic, life sciences, environmental, epigenomics, aws-pds

Tutorials:

1. tutorial:
   • Title: Finding and Downloading TaRGET II Data files
   • URL: https://data.targetepigenomics.org/help/user-guide/download-files
   • AuthorName: TaRGET-DCC
   • AuthorURL: https://data.targetepigenomics.org

Tools & Applications:

1. tools & applications:
   • Title: Visualize TaRGET II data with WashU Epigenome Browser
   • URL: https://epigenomegateway.wustl.edu/browser/
   • AuthorName: WashU Epigenome Browser
   • AuthorURL: https://epigenomegateway.wustl.edu

Publication:

1. publication:

   • Title: The NIEHS TaRGET II Consortium and environmental epigenomics
   • URL: https://doi.org/10.1038/nbt.4099
   • AuthorName: Wang, T., Pehrsson, E., Purushotham, D. et al.

2. publication:

   • Title: Environmental Determinants of cardiovasular disease: lessons learned from air pollution
   • URL: https://pubmed.ncbi.nlm.nih.gov/32382149/
   • AuthorName: Al-Kindi SG, Brook RD, Biswal S, Rajagopalan S.

3. publication:

   • Title: Metabolic effects of air pollution exposure and reversibility
   • URL: https://www.jci.org/articles/view/137315
   • AuthorName: Rajagopalan S, Park B, Palanivel R, et al.

4. publication:

   • Title: Epigenetic biomarkers and preterm birth
   • URL: https://pubmed.ncbi.nlm.nih.gov/32551139/
   • AuthorName: Park B, Khanam R, Vinayachandran V, et.al.

5. publication:

   • Title: The role of environmental exposures and the epigenome in health and disease.
   • URL: https://pubmed.ncbi.nlm.nih.gov/31177562
   • AuthorName: Perera BPU, Faulk C, Svoboda LK, Goodrich JM, Dolinoy DC.

6. publication:

   • Title: Comparison of differential accessibility analysis strategies for ATAC-seq data
   • URL: https://pubmed.ncbi.nlm.nih.gov/32576878/
   • AuthorName: Gontarz P, Fu S, Xing X, Liu S, Miao B et.al.