dandiarchive-dataset/s3://dandiarchive/dandisets/001434/draft/dandiset.yaml

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about:
- identifier: https://www.ebi.ac.uk/ols4/ontologies/uberon/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FUBERON_0002435
  name: striatum
  schemaKey: Anatomy
- identifier: http://purl.obolibrary.org/obo/CHEBI_15355
  name: acetylcholine
  schemaKey: Anatomy
access:
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  status: dandi:OpenAccess
assetsSummary:
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citation: Bouabid, Safa; Zhang, Liangzhu; Vu, Mai-Anh T.; Tang, Kylie; Graham, Benjamin
  M.; Noggle, Christian A.; Howe, Mark W. (2025) Distinct spatially organized striatum-wide
  acetylcholine dynamics for the learning and extinction of Pavlovian associations
  (Version draft) [Data set]. DANDI Archive. https://dandiarchive.org/dandiset/001434/draft
contributor:
- email: sbouabid@bu.edu
  identifier: 0000-0003-4184-3795
  includeInCitation: true
  name: Bouabid, Safa
  roleName:
  - dcite:Author
  - dcite:ContactPerson
  schemaKey: Person
- includeInCitation: true
  name: Zhang, Liangzhu
  roleName:
  - dcite:Author
  schemaKey: Person
- affiliation: []
  email: maianhvu@bu.edu
  identifier: 0000-0003-4766-1159
  includeInCitation: true
  name: Vu, Mai-Anh T.
  roleName:
  - dcite:Author
  schemaKey: Person
- includeInCitation: true
  name: Tang, Kylie
  roleName:
  - dcite:Author
  schemaKey: Person
- includeInCitation: true
  name: Graham, Benjamin M.
  roleName:
  - dcite:Author
  schemaKey: Person
- includeInCitation: true
  name: Noggle, Christian A.
  roleName:
  - dcite:Author
  schemaKey: Person
- email: mwhowe@bu.edu
  identifier: 0000-0002-6865-5084
  includeInCitation: true
  name: Howe, Mark W.
  roleName:
  - dcite:Author
  - dcite:ContactPerson
  schemaKey: Person
- awardNumber: ASAP-020370
  identifier: https://ror.org/03arq3225
  name: Michael J. Fox Foundation
  roleName:
  - dcite:Funder
  schemaKey: Organization
- awardNumber: PF-SF-JFA-836662
  identifier: https://ror.org/05mx85j86
  name: Parkinson’s Foundation
  roleName:
  - dcite:Funder
  schemaKey: Organization
- awardNumber: Klingenstein-Simons Fellowship Awards in Neuroscience
  identifier: https://ror.org/01q222b25
  name: ' Esther A. & Joseph Klingenstein Fund'
  roleName:
  - dcite:Funder
  schemaKey: Organization
- identifier: https://ror.org/00her7k05
  name: Whitehall Foundation
  roleName:
  - dcite:Funder
  schemaKey: Organization
- awardNumber: R01 MH125835
  identifier: https://ror.org/04xeg9z08
  name: National Institute of Mental Health
  roleName:
  - dcite:Funder
  schemaKey: Organization
- awardNumber: F32MH120894
  identifier: https://ror.org/04xeg9z08
  name: National Institute of Mental Health
  roleName:
  - dcite:Funder
  schemaKey: Organization
dateCreated: '2025-05-05T19:13:54.408622+00:00'
description: 'Striatal acetylcholine (ACh) signaling is thought to counteract reinforcement
  signals, promoting extinction and behavioral flexibility. Changes in striatal ACh
  signals have been reported during learning, but how ACh signals for learning and
  extinction are spatially organized to enable region specific plasticity is unclear.
  We used array photometry in mice to reveal a topography of opposing changes in ACh
  release across distinct striatal regions. Reward prediction error encoding was localized
  to specific phases of ACh dynamics in anterior dorsal striatum (aDS): positive and
  negative prediction errors were expressed in dips and elevations respectively. Silencing
  ACh release in aDS impaired extinction, suggesting a role for ACh elevations in
  down-regulating cue reward associations. Dopamine release in aDS dipped for cues
  during extinction, inverse to ACh, while glutamate input onto cholinergic interneurons
  was unchanged. These findings pinpoint where and suggest an intrastriatal mechanism
  for how ACh dynamics shape region-specific plasticity to gate learning and promote
  extinction.'
ethicsApproval: []
id: DANDI:001434/draft
identifier: DANDI:001434
license:
- spdx:CC-BY-4.0
manifestLocation:
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name: Distinct spatially organized striatum-wide acetylcholine dynamics for the learning
  and extinction of Pavlovian associations
relatedResource:
- name: Howe Lab GitHub
  relation: dcite:IsSupplementedBy
  repository: GitHub
  resourceType: dcite:Software
  schemaKey: Resource
  url: https://github.com/howelab
- name: howe-lab-to-nwb
  relation: dcite:IsCompiledBy
  repository: GitHub
  resourceType: dcite:Software
  schemaKey: Resource
  url: https://github.com/catalystneuro/howe-lab-to-nwb/
repository: https://dandiarchive.org
schemaKey: Dandiset
schemaVersion: 0.6.9
url: https://dandiarchive.org/dandiset/001434/draft
version: draft
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