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- citation: Vu, Mai-Anh T.; Brown, Eleanor H.; Wen, Michelle J.; Noggle, Christian A.;
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- Zhuo, Yizhou; Li, Yulong; Otchy, Timothy M.; Tian, Lin; Davison, Ian G.; Boas, David
- A.; Howe, Mark W. (2024) Targeted micro-fiber arrays for measuring and manipulating
- localized multi-scale neural dynamics over large, deep brain volumes during behavior
- (Version draft) [Data set]. DANDI archive. https://dandiarchive.org/dandiset/001084/draft
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- description: Neural population dynamics relevant to behavior vary over multiple spatial
- and temporal scales across three-dimensional volumes. Current optical approaches
- lack the spatial coverage and resolution necessary to measure and manipulate naturally
- occurring patterns of large-scale, distributed dynamics within and across deep brain
- regions such as the striatum. We designed a new micro-fiber array approach capable
- of chronically measuring and optogenetically manipulating local dynamics across
- over 100 targeted locations simultaneously in head-fixed and freely moving mice,
- enabling the investigation of cell-type- and neurotransmitter-specific signals over
- arbitrary 3D volumes at a spatial resolution and coverage previously inaccessible.
- We applied this method to resolve rapid dopamine release dynamics across the striatum,
- revealing distinct, modality-specific spatiotemporal patterns in response to salient
- sensory stimuli extending over millimeters of tissue.
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