DagsHub-Datasets
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dandiarchive-dataset


  
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            {"id":"DANDI:000350/0.240822.1759","url":"https://dandiarchive.org/dandiset/000350/0.240822.1759","name":"Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior","about":[],"access":[{"status":"dandi:OpenAccess","schemaKey":"AccessRequirements"}],"license":["spdx:CC-BY-4.0"],"version":"0.240822.1759","@context":"https://raw.githubusercontent.com/dandi/schema/master/releases/0.6.3/context.json","citation":"Mu, Yu; Bennett, Davis V.; Rubinov, Mikail; Lim, Jing-Xuan; Yang, Chao-Tsung; Tanimoto, Masashi; Mensh, Brett D. ; Looger, Loren L.; Narayan, Sujatha; Ahrens, Misha B. (2024) Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior (Version 0.240822.1759) [Data set]. DANDI archive. https://dandiarchive.org/dandiset/000350/0.240822.1759","keywords":["neuroscience","glia","astrocytes","norepinephrine","noradrenaline","learned helplessness","neuromodulation","behavioral states","evidence accumulation","zebrafish"],"protocol":[],"schemaKey":"Dandiset","identifier":"DANDI:000350","repository":"https://dandiarchive.org","contributor":[{"name":"Mu, Yu","email":"muy@janelia.hhmi.org","roleName":["dcite:Author","dcite:Conceptualization","dcite:ContactPerson","dcite:DataCollector","dcite:DataManager"],"schemaKey":"Person","identifier":"0000-0001-9297-4854","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"}],"includeInCitation":true},{"name":"Bennett, Davis V.","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-5056-407X","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"},{"name":"University of Chicago","schemaKey":"Affiliation","identifier":"https://ror.org/024mw5h28"}],"includeInCitation":true},{"name":"Rubinov, Mikail","roleName":["dcite:Author","dcite:FormalAnalysis"],"schemaKey":"Person","identifier":"0000-0002-4787-7075","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"},{"name":"Vanderbilt University","schemaKey":"Affiliation","identifier":"https://ror.org/02vm5rt34"}],"includeInCitation":true},{"name":"Lim, Jing-Xuan","roleName":["dcite:DataManager"],"schemaKey":"Person","identifier":"0000-0002-5983-9164","affiliation":[{"name":"Howard Hughes Medical Institute","schemaKey":"Affiliation","identifier":"https://ror.org/006w34k90"}],"includeInCitation":true},{"name":"Yang, Chao-Tsung","roleName":["dcite:Author"],"schemaKey":"Person","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"}],"includeInCitation":true},{"name":"Tanimoto, Masashi","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-7653-1081","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"}],"includeInCitation":true},{"name":"Mensh, Brett D. ","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0003-2288-054X","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"}],"includeInCitation":true},{"name":"Looger, Loren L.","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-7531-1757","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"}],"includeInCitation":true},{"name":"Narayan, Sujatha","roleName":["dcite:Author"],"schemaKey":"Person","identifier":"0000-0002-3741-1319","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"}],"includeInCitation":true},{"url":"https://www.janelia.org/lab/ahrens-lab","name":"Ahrens, Misha B.","email":"ahrensm@janelia.hhmi.org","roleName":["dcite:Author","dcite:Conceptualization","dcite:ContactPerson","dcite:Investigation","dcite:ProjectLeader","dcite:ProjectManager","dcite:ProjectAdministration"],"schemaKey":"Person","identifier":"0000-0002-3457-4462","affiliation":[{"name":"Janelia Research Campus","schemaKey":"Affiliation","identifier":"https://ror.org/013sk6x84"}],"includeInCitation":true},{"url":"http://www.hhmi.org/","name":"Howard Hughes Medical Institute","roleName":["dcite:Funder"],"schemaKey":"Organization","identifier":"https://ror.org/006w34k90","awardNumber":"325171","contactPoint":[],"includeInCitation":false},{"url":"https://www.simonsfoundation.org","name":"Simons Collaboration on the Global Brain Awards","roleName":["dcite:Funder"],"schemaKey":"Organization","identifier":"https://ror.org/01cmst727","awardNumber":"542943SPI","contactPoint":[],"includeInCitation":false},{"url":"https://www.catalystneuro.com/team/","name":"Baker, Cody","email":"cody.c.baker.phd@gmail.com","roleName":["dcite:Software","dcite:DataCurator"],"schemaKey":"Person","identifier":"0000-0002-0829-4790","affiliation":[{"name":"CatalystNeuro","schemaKey":"Affiliation","identifier":"https://ror.org/01d74sk53"}],"includeInCitation":false}],"dateCreated":"2022-10-30T19:50:01.557863+00:00","description":"When a behavior repeatedly fails to achieve its goal, animals often give up and become passive, which can be strategic for preserving energy or regrouping between attempts. It is unknown how the brain identifies behavioral failures and mediates this behavioral-state switch. In larval zebrafish swimming in virtual reality, visual feedback can be withheld so that swim attempts fail to trigger expected visual flow. After tens of seconds of such motor futility, animals became passive for similar durations. Whole-brain calcium imaging revealed noradrenergic neurons that responded specifically to failed swim attempts and radial astrocytes whose calcium levels accumulated with increasing numbers of failed attempts. Using cell ablation and optogenetic or chemogenetic activation, we found that noradrenergic neurons progressively activated brainstem radial astrocytes, which then suppressed swimming. Thus, radial astrocytes perform a computation critical for behavior: they accumulate evidence that current actions are ineffective and consequently drive changes in behavioral states.","publishedBy":{"id":"urn:uuid:19088d33-db8c-40f1-8af5-e554b0a852ad","name":"DANDI publish","endDate":"2024-08-22T17:59:27.040376+00:00","schemaKey":"PublishActivity","startDate":"2024-08-22T17:59:27.040376+00:00","wasAssociatedWith":[{"id":"urn:uuid:fa2ce8cb-86e0-48cb-9c9c-593a6bd3d874","name":"DANDI API","version":"0.1.0","schemaKey":"Software","identifier":"RRID:SCR_017571"}]},"studyTarget":["motor activity","whole-brain","radial astrocytes"],"assetsSummary":{"species":[{"name":"Danio rerio - Zebra fish","schemaKey":"SpeciesType","identifier":"http://purl.obolibrary.org/obo/NCBITaxon_7955"}],"approach":[{"name":"microscopy approach; cell population imaging","schemaKey":"ApproachType"}],"schemaKey":"AssetsSummary","dataStandard":[{"name":"Neurodata Without Borders (NWB)","schemaKey":"StandardsType","identifier":"RRID:SCR_015242"}],"numberOfBytes":5865794202897,"numberOfFiles":12,"numberOfSubjects":12,"variableMeasured":["TwoPhotonSeries","OpticalChannel","ProcessingModule","ImagingPlane","PlaneSegmentation"],"measurementTechnique":[{"name":"surgical technique","schemaKey":"MeasurementTechniqueType"},{"name":"two-photon microscopy technique","schemaKey":"MeasurementTechniqueType"},{"name":"analytical technique","schemaKey":"MeasurementTechniqueType"}]},"datePublished":"2024-08-22T17:59:27.040376+00:00","schemaVersion":"0.6.3","ethicsApproval":[],"wasGeneratedBy":[],"relatedResource":[{"url":"https://www.sciencedirect.com/science/article/pii/S009286741930621X","name":"Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior","relation":"dcite:IsDescribedBy","schemaKey":"Resource","identifier":"https://doi.org/10.1016/j.cell.2019.05.050","repository":"Cell"}],"manifestLocation":["https://dandiarchive.s3.amazonaws.com/dandisets/000350/0.240822.1759/assets.yaml"]}