dandiarchive-dataset/s3://dandiarchive/dandisets/000339/draft/dandiset.yaml

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access:
- schemaKey: AccessRequirements
  status: dandi:OpenAccess
assetsSummary:
  approach:
  - name: electrophysiological approach
    schemaKey: ApproachType
  dataStandard:
  - identifier: RRID:SCR_015242
    name: Neurodata Without Borders (NWB)
    schemaKey: StandardsType
  measurementTechnique:
  - name: multi electrode extracellular electrophysiology recording technique
    schemaKey: MeasurementTechniqueType
  - name: surgical technique
    schemaKey: MeasurementTechniqueType
  - name: analytical technique
    schemaKey: MeasurementTechniqueType
  - name: signal filtering technique
    schemaKey: MeasurementTechniqueType
  numberOfBytes: 64243853984
  numberOfFiles: 66
  numberOfSubjects: 30
  schemaKey: AssetsSummary
  species:
  - identifier: http://purl.obolibrary.org/obo/NCBITaxon_10116
    name: Rattus norvegicus - Norway rat
    schemaKey: SpeciesType
  variableMeasured:
  - ProcessingModule
  - ElectricalSeries
  - LFP
  - ElectrodeGroup
citation: Ramachandran, Sandhya; Carnegie Mellon University; Niu, Xiaodan; Yu, Kai;
  He, Bin (2024) Local Field Potential Recordings in the Primary Somatosensory Cortex
  before and after Transcranial Focused Ultrasound Stimulation in Rats (Version draft)
  [Data set]. DANDI archive. https://dandiarchive.org/dandiset/000339/draft
contributor:
- affiliation: []
  email: s.ramachandran8@gmail.com
  includeInCitation: true
  name: Ramachandran, Sandhya
  roleName:
  - dcite:ContactPerson
  schemaKey: Person
- contactPoint: []
  identifier: https://ror.org/05x2bcf33
  includeInCitation: true
  name: Carnegie Mellon University
  roleName:
  - dcite:Affiliation
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- affiliation:
  - identifier: https://ror.org/05x2bcf33
    name: Carnegie Mellon University
    schemaKey: Affiliation
  email: xiaodann@andrew.cmu.edu
  includeInCitation: true
  name: Niu, Xiaodan
  roleName:
  - dcite:Author
  schemaKey: Person
- affiliation:
  - identifier: https://ror.org/05x2bcf33
    name: Carnegie Mellon University
    schemaKey: Affiliation
  email: yukai@cmu.edu
  includeInCitation: true
  name: Yu, Kai
  roleName:
  - dcite:Author
  schemaKey: Person
- affiliation:
  - identifier: https://ror.org/05x2bcf33
    name: Carnegie Mellon University
    schemaKey: Affiliation
  email: bhe1@andrew.cmu.edu
  includeInCitation: true
  name: He, Bin
  roleName:
  - dcite:Author
  schemaKey: Person
- contactPoint: []
  includeInCitation: false
  name: NIH MH114233
  roleName:
  - dcite:Funder
  schemaKey: Organization
- contactPoint: []
  includeInCitation: false
  name: 'NIH NS124564 '
  roleName:
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dateCreated: '2022-09-26T20:33:09.788694+00:00'
description: 'In this study, we investigate how transcranial focused ultrasound (tFUS)
  modulates neural interaction and response to peripheral electrical stimulation at
  hindlimb through intracranial multi-electrode recordings in the rat somatosensory
  cortex. Recordings were performed using a 32-channel NeuroNexus® multi-electrode
  array. Rats were anesthetized using isoflurane at 2%. Recordings were taken while
  delivering peripheral electrical stimulation once every 5 seconds to analyze the
  neural response in the rat S1HL region, before ultrasound for 30 minutes and then
  afterwards for an hour, in order to determine how the ultrasound modulated the electrical
  stimulation induced local field potential (LFP) waveforms. We delivered ultrasound
  for 5 minutes in a pulsed pattern at 5 levels of sonication repetition frequencies
  (SRF) (10 Hz, 50 Hz, 75 Hz, 100 Hz, and 125 Hz) to induce frequency dependent plasticity
  in a manner similar to that is found following tetanic electrical stimulation. We
  investigated whether delivering tFUS that alters connectivity/correlation between
  the targeted neurons may alter collective responses manifested in the modulated
  LFP waveforms. The applied fundamental frequency of ultrasound was 0.5 MHz, the
  pulse repetition frequency (PRF) was 3 kHz, and the total duty cycle was 36%. This
  dataset contains LFP recordings, with 32 channels for each datafile.

  In each subject, recordings are provided with "pre" and "post" tFUS for two different
  frequencies (SRF), and most contain recordings during the delivery of ultrasound
  and during rest periods between sessions of different ultrasound parameters. For
  example, a single subject may include "100Hz_pre", "100Hz_post", "50Hz_pre", "50Hz_post",
  which are the pre and post tFUS recordings for the two used parameters, and then
  "50Hz" and "100Hz", which are the recordings taken during stimulation, and "rest1"
  and "rest2", which are the rest periods between sessions. These names are preceded
  by a label such as "BH280", which is the animal subject label. Ultrasound is delivered
  in a continuous paradigm, with pulses delivered at the stimulation repetition frequency
  continuously throughout the 5 minutes of stimulation. During the "pre" and "post"
  recordings, the peripheral electrical stimulation is delivered once every 5 seconds
  approximately. Electrical stimulation event trigger is not included in the dataset
  as it was not recorded due to using a separate system to deliver the electrical
  stimulation. We were using threshold detection on a channel of LFP recordings in
  order to detect the electrical stimulation events, in which events can be recognized
  by the quick rising of voltage. One could also approximate it by detecting the first
  event, and then add periods of 5 seconds to generate the rest of the trigger times.

  More details about the experimental details can be found in our paper published
  by Journal of Neural Engineering (DOI: 10.1088/1741-2552/ac889f).'
ethicsApproval: []
id: DANDI:000339/draft
identifier: DANDI:000339
keywords:
- Ultrasound
- tFUS
- Plasticity
- Somatosensory
- Rat
- Somatosensory Cortex
license:
- spdx:CC-BY-4.0
manifestLocation:
- https://api.dandiarchive.org/api/dandisets/000339/versions/draft/assets/
name: Local Field Potential Recordings in the Primary Somatosensory Cortex before
  and after Transcranial Focused Ultrasound Stimulation in Rats
protocol: []
relatedResource: []
repository: https://dandiarchive.org
schemaKey: Dandiset
schemaVersion: 0.6.3
studyTarget:
- Somatosensory Cortex
- Rat
- Plasticity
url: https://dandiarchive.org/dandiset/000339/draft
version: draft
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