dandiarchive-dataset/s3://dandiarchive/dandisets/001292/draft/dandiset.yaml

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acknowledgement: This study was supported by the National Institutes of Health grants
  R01- MH120136 to F.H.D.M. and R01-MH131570 to F.H.D.M. and M.B., the Canadian Institute
  of Health Research grant PJT-168855 to G.J.K., and the Russell and Diana Hawkins
  Family Foundation Discovery Fellowship and the Dr. John J. Kopchick Fellowship to
  X.O.Z. We thank Nikita Watson, Joseph Campbell, and Sharon Gordon for their technical
  and administrative assistance. We also thank Christian Bravo-Rivera and members
  of the Mario Penzo lab for their valuable comments on the manuscript.
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citation: Guillermo Aquino-Miranda; Dounya Jalloul; Xu O. Zhang; Sa Li; Gilbert J.
  Kirouac; Michael Beierlein; Fabricio H. Do Monte (2025) Functional properties of
  corticothalamic circuits targeting paraventricular thalamic neurons (Version draft)
  [Data set]. DANDI Archive. https://dandiarchive.org/dandiset/001292/draft
contributor:
- email: guillermo.aquinomiranda@uth.tmc.edu
  includeInCitation: true
  name: Guillermo Aquino-Miranda
  schemaKey: Person
- email: dounya.jalloul@uth.tmc.edu
  includeInCitation: true
  name: Dounya Jalloul
  schemaKey: Person
- email: xu.zhang@ucla.edu
  includeInCitation: true
  name: Xu O. Zhang
  schemaKey: Person
- email: sa.li@umanitoba.ca
  includeInCitation: true
  name: Sa Li
  schemaKey: Person
- email: gilbert.kirouac@umanitoba.ca
  includeInCitation: true
  name: Gilbert J. Kirouac
  schemaKey: Person
- email: michael.beierlein@uth.tmc.edu
  includeInCitation: true
  name: Michael Beierlein
  schemaKey: Person
- affiliation: []
  email: fabricio.h.domonte@uth.tmc.edu
  includeInCitation: true
  name: Fabricio H. Do Monte
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dateCreated: '2025-01-19T19:25:07.111932+00:00'
description: Corticothalamic projections to sensorimotor thalamic nuclei show modest
  firing rates and serve to modulate the activity of thalamic relay neurons. By contrast,
  here we find that high-order corticothalamic projections from the prelimbic (PL)
  cortex to the anterior paraventricular thalamic nucleus (aPVT) maintain high-frequency
  activity and evoke strong synaptic excitation of aPVT neurons in rats. In a significant
  fraction of aPVT cells, such high-frequency excitation of PL-aPVT projections leads
  to a rapid decay of action potential amplitudes, followed by a depolarization block
  (DB) that strongly limits aPVT maximum firing rates, thereby regulating both defensive
  and appetitive behaviors in a frequency-dependent manner. Strong inhibitory inputs
  from the anteroventral portion of the thalamic reticular nucleus (avTRN) inhibit
  the firing rate of aPVT neurons during periods of high-spike fidelity but restore
  it during prominent DB, suggesting that avTRN activity can modulate the effects
  of PL inputs on aPVT firing rates to ultimately control motivated behaviors.
ethicsApproval: []
id: DANDI:001292/draft
identifier: DANDI:001292
keywords:
- active avoidance; defensive behavior; depolarization block; feedforward inhibition;
  food seeking; midline thalamus; prelimbic prefrontal cortex; short-term synaptic
  plasticity; thalamic reticular nucleus.
license:
- spdx:CC-BY-4.0
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name: Functional properties of corticothalamic circuits targeting paraventricular
  thalamic neurons
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repository: https://dandiarchive.org
schemaKey: Dandiset
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url: https://dandiarchive.org/dandiset/001292/draft
version: draft
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