DagsHub-Datasets
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dandiarchive-dataset


  
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            {"id":"DANDI:001048/draft","url":"https://dandiarchive.org/dandiset/001048/draft","name":"Plasma membrane conductance changes in response to supraphysiological hyperpolarization","about":[],"access":[{"status":"dandi:OpenAccess","schemaKey":"AccessRequirements"}],"license":["spdx:CC-BY-4.0"],"version":"draft","@context":"https://raw.githubusercontent.com/dandi/schema/master/releases/0.6.7/context.json","citation":"Silkuniene, Giedre; Silkunas, Mantas; Olga, Pakhomova; Andrei, Pakhomov (2025) Plasma membrane conductance changes in response to supraphysiological hyperpolarization (Version draft) [Data set]. DANDI Archive. https://dandiarchive.org/dandiset/001048/draft","schemaKey":"Dandiset","identifier":"DANDI:001048","repository":"https://dandiarchive.org","contributor":[{"name":"Silkuniene, Giedre","email":"giedre.silkuniene@gmail.com","roleName":["dcite:ContactPerson"],"schemaKey":"Person","identifier":"0000-0001-8436-9718","affiliation":[],"includeInCitation":true},{"name":"Silkunas, Mantas","schemaKey":"Person","identifier":"0000-0002-4568-9265","includeInCitation":true},{"name":"Olga, Pakhomova","schemaKey":"Person","identifier":"0000-0003-4950-4130","includeInCitation":true},{"name":"Andrei, Pakhomov","roleName":["dcite:ProjectLeader"],"schemaKey":"Person","identifier":"0000-0003-3816-3860","includeInCitation":true},{"name":"National Institutes of Health","roleName":["dcite:Funder"],"schemaKey":"Organization","awardNumber":"1R21EY034258","includeInCitation":false},{"name":"National Institutes of Health","roleName":["dcite:Funder"],"schemaKey":"Organization","awardNumber":"5R21EY034803","includeInCitation":false}],"dateCreated":"2024-06-05T00:38:54.126397+00:00","description":"This study aimed to visualize and characterize membrane lesions caused by hyperpolarization and their protective roles against membrane overcharging. We identified three types of lesions in HEK cells, each with distinct characteristics. Hyperpolarization to specific voltages created diffuse zonal electropermeabilization, focal pores, and high-conductance pores, with adaptive conductance changes preventing membrane rupture. This study was partially supported by NIH grants 1R21EY034258 and 5R21EY034803.","assetsSummary":{"schemaKey":"AssetsSummary","numberOfBytes":0,"numberOfFiles":0},"schemaVersion":"0.6.7","ethicsApproval":[],"wasGeneratedBy":[{"name":"Next Generation Temporal Interference Stimulation for Non-Invasive Neuromodulation","schemaKey":"Project","identifier":"5R21EY034803"},{"name":"Targeted Neuromodulation by Nanosecond Pulsed Electric Fields","schemaKey":"Project","identifier":"1R21EY034258"}],"relatedResource":[{"url":"https://doi.org/10.1016/j.xcrp.2025.102660","name":"Excitation and polarization of isolated neurons by high-frequency sine waves for temporal interference stimulation","relation":"dcite:IsPublishedIn","schemaKey":"Resource","identifier":"doi.org/10.1016/j.xcrp.2025.102660","resourceType":"dcite:JournalArticle"}],"manifestLocation":["https://api.dandiarchive.org/api/dandisets/001048/versions/draft/assets/"]}