DagsHub-Datasets
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dandiarchive-dataset


  
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            {"id":"DANDI:000469/0.240122.1812","doi":"10.80507/dandi.123456/0.123456.1234","url":"https://dandiarchive.org/dandiset/000469/0.240122.1812","name":"Dataset of human-single neuron activity during a Sternberg working memory task.","about":[{"name":"Medial Temporal Lobe","schemaKey":"GenericType"},{"name":"Medial Frontal Cortex","schemaKey":"Anatomy"}],"access":[{"status":"dandi:OpenAccess","schemaKey":"AccessRequirements"}],"license":["spdx:CC-BY-4.0"],"version":"0.240122.1812","@context":"https://raw.githubusercontent.com/dandi/schema/master/releases/0.6.4/context.json","citation":"Kyzar, Michael; Kaminski, Jan; Brzezicka, Aneta; Reed, Chrystal M.; Chung, Jeffrey M. ; Mamelak, Adam M.; Rutishauser, Ueli (2024) Dataset of human-single neuron activity during a Sternberg working memory task (Version 0.240122.1812) [Data set]. DANDI archive. https://doi.org/10.80507/dandi.123456/0.123456.1234","keywords":["cognitive neuroscience","data standardization","working memory","neurophysiology","neurosurgery","NWB","open source","single-neurons"],"protocol":[],"schemaKey":"Dandiset","identifier":"DANDI:000469","repository":"https://dandiarchive.org","contributor":[{"name":"Kyzar, Michael","email":"kyzarnexus@gmail.com","roleName":["dcite:ContactPerson","dcite:Author","dcite:DataCurator","dcite:DataManager","dcite:FormalAnalysis","dcite:Investigation","dcite:Maintainer","dcite:Methodology","dcite:ProjectLeader","dcite:ProjectManager","dcite:ProjectMember","dcite:Researcher","dcite:Software","dcite:Validation","dcite:Visualization"],"schemaKey":"Person","identifier":"0009-0004-4392-9933","affiliation":[{"name":"Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA","schemaKey":"Affiliation"}],"includeInCitation":true},{"name":"Kaminski, Jan","roleName":[],"schemaKey":"Person","identifier":"0000-0002-8663-7314","affiliation":[],"includeInCitation":true},{"name":"Brzezicka, Aneta","roleName":["dcite:Author","dcite:DataCollector"],"schemaKey":"Person","identifier":"0000-0003-1950-4180","affiliation":[],"includeInCitation":true},{"name":"Reed, Chrystal M.","roleName":[],"schemaKey":"Person","identifier":"0000-0002-7157-3645","affiliation":[],"includeInCitation":true},{"name":"Chung, Jeffrey M. ","roleName":[],"schemaKey":"Person","affiliation":[],"includeInCitation":true},{"name":"Mamelak, Adam M.","roleName":[],"schemaKey":"Person","identifier":"0000-0002-4245-6431","affiliation":[],"includeInCitation":true},{"name":"Rutishauser, Ueli","email":"Ueli.Rutishauser@cshs.org","roleName":["dcite:Author","dcite:Conceptualization","dcite:ProjectMember","dcite:FundingAcquisition","dcite:Resources","dcite:Software","dcite:Supervision","dcite:Validation","dcite:ContactPerson"],"schemaKey":"Person","identifier":"0000-0002-9207-7069","affiliation":[{"name":"Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA","schemaKey":"Affiliation"},{"name":"Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA","schemaKey":"Affiliation"},{"name":"Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA","schemaKey":"Affiliation"},{"name":"Computational and Neural Systems Program, California Institute of Technology, Pasadena, CA, USA","schemaKey":"Affiliation"},{"name":"Center for Neural Science and Medicine, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA","schemaKey":"Affiliation"}],"awardNumber":"","includeInCitation":true},{"name":"National Institute of Mental Health","roleName":["dcite:Sponsor"],"schemaKey":"Organization","awardNumber":"R01MH110831","contactPoint":[],"includeInCitation":false},{"name":"Sullivan, Shannon","roleName":["dcite:DataCollector","dcite:Validation"],"schemaKey":"Person","identifier":"0000-0002-1137-8987","affiliation":[],"includeInCitation":false},{"name":"National Insitute of Neurological Disorders and Stroke","roleName":["dcite:Sponsor"],"schemaKey":"Organization","awardNumber":"U01NS117839, U01NS098961","contactPoint":[],"includeInCitation":false}],"dateCreated":"2023-03-30T17:37:36.429935+00:00","description":"We present a dataset of 1809 single neurons recorded from the human medial temporal lobe (amygdala and hippocampus) and medial frontal lobe (anterior cingulate cortex, pre-supplementary motor area, ventral medial prefrontal cortex) across 41 sessions from 21 patients that underwent intracranial monitoring for epileptic activity. Subjects first performed a screening task (907 neurons), based on which we identified images for which highly selective cells were present in the medial temporal lobe. Subjects then performed a working memory task (902 neurons), in which they were sequentially presented with 1-3 images, and following a maintenance period, were asked if a probe was identical to one of the currently maintained images. This Neural data without borders (NWB) formatted dataset includes spike times, extracellular spike waveforms, stimuli presented, behavior, electrode locations, and subject demographics. As validation, we replicate previous findings on the existence of concept cells and their persistent activity during working memory maintenance. This dataset provides a substantial amount of rare human single neuron recordings together with behavior, thereby enabling investigation of the neural mechanisms of working memory at the single-neuron level.\n\nThis code accompanies the following data descriptor: \n* Kyzar M, Kamiński J, Brzezicka A, Reed CM, Chung JM, Mamelak AN, Rutishauser U. Dataset of human-single neuron activity during a Sternberg working memory task. Sci Data. 2024 Jan 18;11(1):89. doi: 10.1038/s41597-024-02943-8. PMID: 38238342; PMCID: PMC10796636.\n  [Link to Paper](https://pubmed.ncbi.nlm.nih.gov/38238342/)\n* Sample code to access and analyze this dataset has been provided: https://github.com/rutishauserlab/workingmem-release-NWB\n","publishedBy":{"id":"urn:uuid:133a8321-44d0-434d-bb9e-73e504717b17","name":"DANDI publish","endDate":"2024-01-22T18:12:47.193616+00:00","schemaKey":"PublishActivity","startDate":"2024-01-22T18:12:47.193616+00:00","wasAssociatedWith":[{"id":"urn:uuid:4457c644-fcaf-4175-bbe0-d1c36c977f9f","name":"DANDI API","version":"0.1.0","schemaKey":"Software","identifier":"RRID:SCR_017571"}]},"studyTarget":[],"assetsSummary":{"species":[{"name":"Homo sapiens - Human","schemaKey":"SpeciesType","identifier":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"approach":[{"name":"electrophysiological approach","schemaKey":"ApproachType"}],"schemaKey":"AssetsSummary","dataStandard":[{"name":"Neurodata Without Borders (NWB)","schemaKey":"StandardsType","identifier":"RRID:SCR_015242"}],"numberOfBytes":9788560252,"numberOfFiles":41,"numberOfSubjects":21,"variableMeasured":["Units","ElectrodeGroup"],"measurementTechnique":[{"name":"surgical technique","schemaKey":"MeasurementTechniqueType"},{"name":"spike sorting technique","schemaKey":"MeasurementTechniqueType"}]},"datePublished":"2024-01-22T18:12:47.193616+00:00","schemaVersion":"0.6.4","ethicsApproval":[],"wasGeneratedBy":[],"relatedResource":[{"url":"https://www.nature.com/articles/s41597-024-02943-8","name":"Dataset of human-single neuron activity during a Sternberg working memory task","relation":"dcite:IsSupplementTo","schemaKey":"Resource","identifier":"doi.org/10.1038/s41597-024-02943-8","repository":"Scientific Data"},{"url":"https://github.com/rutishauserlab/workingmem-release-NWB","name":"Source code for: Dataset of human-single neuron activity during a Sternberg working memory task","relation":"dcite:IsSupplementedBy","schemaKey":"Resource","identifier":"https://doi.org/10.5281/zenodo.8161627","repository":"workingmem-release-NWB"},{"url":"https://www.nature.com/articles/nn.4509","name":"Persistently active neurons in human medial frontal and medial temporal lobe support working memory","relation":"dcite:IsDerivedFrom","schemaKey":"Resource","identifier":"10.1038/nn.4509","repository":"Nature Neuroscience"},{"url":"https://www.sciencedirect.com/science/article/pii/S0896627320300581?via%3Dihub","name":"Combined Phase-Rate Coding by Persistently Active Neurons as a Mechanism for Maintaining Multiple Items in Working Memory in Humans","relation":"dcite:IsDerivedFrom","schemaKey":"Resource","identifier":"10.1016/j.neuron.2020.01.032","repository":"Neuron"}],"manifestLocation":["https://dandiarchive.s3.amazonaws.com/dandisets/000469/0.240122.1812/assets.yaml"]}